Resource Type

Journal Article 535

Conference Videos 6

Year

2024 1

2023 36

2022 56

2021 54

2020 31

2019 47

2018 32

2017 41

2016 22

2015 26

2014 23

2013 27

2012 12

2011 21

2010 16

2009 25

2008 18

2007 18

2006 4

2005 3

open ︾

Keywords

fuel cell 13

immunotherapy 13

COVID-19 6

lung cancer 6

solar cell 6

hematopoietic stem cell transplantation 5

hydrogen energy 5

prognosis 5

stem cell 5

SARS-CoV-2 4

cell proliferation 4

control 4

immune checkpoint inhibitor 4

microbial fuel cell 4

solid oxide fuel cell 4

breast cancer 3

chemotherapy 3

hepatocellular carcinoma 3

solid oxide fuel cell (SOFC) 3

open ︾

Search scope:

排序： Display mode:

A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 711-725 doi: 10.1007/s11684-020-0808-3

Abstract: Based on recent clinical data, approximately 50% of patients with relapsed or refractory B-cell lymphomaachieved complete remission after receiving the CD19 CAR-T cell therapy.Nonetheless, the CAR-T therapy was usually associated with potentially lethal adverse effects, such asTherefore, optimizing the structure of CAR, creating new drugs, and combining CAR-T cell therapy withthe toxicity in patients with lymphoma after the CAR-T cell therapy.

Keywords： chimeric antigen receptor T (CAR-T) cell     lymphoma     cytokine release syndrome (CRS)     immune effector cell-associated    

HTML PDF Collect

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Frontiers of Medicine 2021, Volume 15, Issue 1,   Pages 33-42 doi: 10.1007/s11684-019-0735-3

Abstract: Immunotherapy has recently led to a paradigm shift in cancer therapy, in which immune checkpoint inhibitorsHowever, given the nature of the non-specific activation of effector T cells, ICIs are remarkably associatedwith a substantial risk of immune-related adverse events (irAEs) in almost all organs or systems.Cytotoxic lymphocyte antigen-4 and programmed cell death protein-1/programmed cell death ligand 1 inhibitors

Keywords： cancer     immunotherapy     immune checkpoint inhibitors     immune-related adverse events     review    

HTML PDF Collect

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Frontiers of Medicine   Pages 878-888 doi: 10.1007/s11684-023-0993-y

Abstract: A total of 182 patients with metastatic UM treated with immune checkpoint blockade (ICB) were includedOur data suggest that the combination of LDT with ICB may be associated with a survival benefit and higher

Keywords： uveal melanoma     liver-directed therapy     immune checkpoint blockade     SIRT     anti-PD-1     anti-CTLA-4    

HTML PDF Collect

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 269-279 doi: 10.1007/s11684-018-0621-4

Abstract: NK cell activation, well known for its role in the immune surveillance against tumor and pathogen-infectedIn addition to the innate direct “killer” functions, NK cell activity contributes to regulateUnder the setting of liver diseases, NK cells are of great importance for stimulating or inhibiting immuneresponses, leading to either immune activation or immune tolerance.Here, we focus on the relationship between NK cell biology, such as their phenotypic features and functional

Keywords： natural killer cell     phenotype     immune activation     immune tolerance     liver diseases    

HTML PDF Collect

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: By conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitiveoligodendrocyte precursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in aSome specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytesFor example, glial/glioma stem cell markers OLIG1/PTPRZ1 and B cell-specific receptorsTheir expression was positively correlated with those of immune checkpoint genes (e.g., LGALS3

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

HTML PDF Collect

Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 104-113 doi: 10.15302/J-FASE-2014003

Abstract: from its original cellular state to a totipotent state is essential for term development after somatic cellThe nuclear-associated factors contained within oocytes are critical for normal fertilization by spermor for somatic cell nuclear reprogramming.

Keywords： nuclear reprogramming     somatic cell     transcription factors     transcriptomics    

HTML PDF Collect

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 18-42 doi: 10.1007/s11684-022-0976-4

Abstract: With the improved understanding of driver mutations in non-small cell lung cancer (NSCLC), expandingFurthermore, the therapeutic role of immune-checkpoint inhibitors (ICIs) in oncogene-driven NSCLC remainsdriver mutations and the combined therapeutic approaches that might reverse the immunosuppressive tumor immune

Keywords： non-small cell lung cancer     driver mutations     treatment strategy     resistant mechanism     immune-checkpoint    

HTML PDF Collect

Immunometabolism: a new dimension in immunotherapy resistance

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 585-616 doi: 10.1007/s11684-023-1012-z

Abstract: Immune checkpoint inhibitors (ICIs) have demonstrated unparalleled clinical responses and revolutionizedCorrespondingly, people used to pay more attention to the effect of tumor cell metabolism on immunocytesof metabolic intervention with ICIs to reap synergic benefits and facilitate an adjusted anti-tumor immune

Keywords： immune cell     immunometabolism     metabolic reprogramming     immunotherapy     resistance     tumor microenvironment     immune checkpoint inhibitor    

HTML PDF Collect

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 596-609 doi: 10.1007/s11684-021-0868-z

Abstract: Sialic acid binding Ig-like lectin 10 (Siglec10) is a member of innate immune checkpoints that inhibitsthe activation of immune cells through the interaction with its ligand CD24 on tumor cells.In particular, Siglec10 was upregulated in patients with kidney renal clear cell carcinoma (KIRC) and was inversely associated with the prognosis of the patients.Moreover, higher level of Siglec10 was associated with advanced disease (stages III and IV) and worse

Keywords： innate immune checkpoint     Siglec10     kidney renal clear cell carcinoma    

HTML PDF Collect

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 138-151 doi: 10.1007/s11684-018-0627-y

Abstract: As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) haveregulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic celltype for immune disorders.on the basis of our previous work, we proposed three new concepts of MSCs, i.e., “subtotipotent stem celldatabase (http://clinicaltrials.gov) on registered clinical trials using MSCs to treat a variety of immune

Keywords： mesenchymal stem cell     clinical transition     immune disorders    

HTML PDF Collect

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Frontiers of Medicine 2018, Volume 12, Issue 4,   Pages 440-450 doi: tzg@ustc.edu.cn

Abstract: Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cellHowever, considering the safety, activities, and reliability of the cell products, researchers must developIn this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed

Keywords： natural killer cells     immunotherapy     adoptive transfer     genetic modification     immune checkpoint inhibitor    

HTML Collect

Potential of electron transfer and its application in dictating routes of biochemical processes associated

Frontiers of Medicine 2021, Volume 15, Issue 5,   Pages 679-692 doi: 10.1007/s11684-021-0866-1

Abstract: enforced selective reprogramming could be predicted by examining the net changes of the PET values associated

Keywords： metabolic reprogramming     potential of electron transfer     cell proliferation     aerobic glycolysis     cancer    

HTML PDF Collect

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host Review

Bruce R. Blazar

Engineering 2019, Volume 5, Issue 1,   Pages 98-105 doi: 10.1016/j.eng.2018.11.016

Abstract: capable of mediating or supporting alloresponses; however, this renders the recipients functionally T cellAs our knowledge of immune system homeostasis has increased, cell populations with immune regulatoryAlthough such cell populations are typically present in low frequencies, methods to isolate and expandand preclinical proof of concept of GVHD models, along with GVHD outcomes that focus exclusively on immuneregulatory cell therapies that have progressed to clinical testing.

Keywords： Graft-versus-host disease (GVHD)     Immune regulatory cells     Cell therapy    

HTML PDF Collect

Comparison of reference values for immune recovery between event-free patients receiving haploidentical

Xuying Pei, Xiangyu Zhao, Yu Wang, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Yingjun Chang, Xiaojun Huang

Frontiers of Medicine 2018, Volume 12, Issue 2,   Pages 153-163 doi: 10.1007/s11684-017-0548-1

Abstract:

To establish optimal reference values for recovered immune cell subsets, we prospectively investigatedpost-transplant immune reconstitution (IR) in 144 patients who received allogeneic stem cell transplantationwith an IR comparable to the reference values display superior survival, and the levels of recovery in immunesuggest that data from this recipient cohort should be used as reference values for post-transplant immunecell counts in patients receiving HSCT.

Keywords： immune reconstitution     hematopoietic stem cell transplantation     event-free patients     reference range    

HTML PDF Collect

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Frontiers of Medicine 2023, Volume 17, Issue 4,   Pages 699-713 doi: 10.1007/s11684-022-0972-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50% long-term complete response in relapsed or refractory diffuse large B-cell lymphoma (DLBCLImmunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansionour findings provided a clinical rationale for targeting tumor microenvironments and reprogramming immuneCAR-T cell therapy.

Keywords： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

HTML PDF Collect

Title Author Date Type Operation

A giant step forward: chimeric antigen receptor T-cell therapy for lymphoma

Houli Zhao, Yiyun Wang, Elaine Tan Su Yin, Kui Zhao, Yongxian Hu, He Huang

Journal Article

Advances on immune-related adverse events associated with immune checkpoint inhibitors

Yong Fan, Yan Geng, Lin Shen, Zhuoli Zhang

Journal Article

Liver-directed treatment is associated with improved survival and increased response to immune checkpoint

Journal Article

Natural killer cells in liver diseases

Meijuan Zheng, Haoyu Sun, Zhigang Tian

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell

Journal Article

Oocyte-associated transcription factors in reprogramming after somatic cell nuclear transfer: a review

Fengxia YIN,Hui LIU,Shorgan BOU,Guangpeng LI

Journal Article

Treatment of advanced non-small cell lung cancer with driver mutations: current applications and future

Journal Article

Immunometabolism: a new dimension in immunotherapy resistance

Journal Article

Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient

Journal Article

Mesenchymal stem cells and immune disorders: from basic science to clinical transition

Shihua Wang, Rongjia Zhu, Hongling Li, Jing Li, Qin Han, Robert Chunhua Zhao

Journal Article

Challenges of NK cell-based immunotherapy in the new era

Fang Fang, Weihua Xiao, Zhigang Tian

Journal Article

Potential of electron transfer and its application in dictating routes of biochemical processes associated

Journal Article

Immune Regulatory Cell Biology and Clinical Applications to Prevent or Treat Acute Graft-Versus-Host

Bruce R. Blazar

Journal Article

Comparison of reference values for immune recovery between event-free patients receiving haploidentical

Xuying Pei, Xiangyu Zhao, Yu Wang, Lanping Xu, Xiaohui Zhang, Kaiyan Liu, Yingjun Chang, Xiaojun Huang

Journal Article

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

Journal Article